Skype Vs. Hyrbid Comparison
Doug Kaye is one guy who REALLY knows Audio (He is the man behind IT conversations). At the very first Portable Media Expo I attended a seminar on better audio quality, and it was one of the most informative seminars I attended.
Doug and Paul Figgiani go over many examples of Skype vs hybrids.
You can hear the different examples side by side. Here are some other tips they recommend.
Use a USB headset.
Close any programs that are running in the background (like iTunes, IM,).
Have a good connection (100kbps) to be safe
About the 6 minute mark he really gets into some other great tips. Very informative.
Check it out at
http://www.blogarithms.com/index.php/archives/2007/12/23/skype-for-interviews/